Big Endothelin-1 (22-38), human

• UNSPSC Description:

  Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38)[1].

• Target Antigen:

  Others

• Type:

  Peptides

• Related Pathways:

  Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/big-endothelin-1-22-38-human.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)[C@H](N)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N1[C@@H](CCC1)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N2[C@@H](CCC2)C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(NCC(N[C@@H](CO)C(N3[C@@H](CCC3)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)CC5=CN=CN5)=O)=O)=O)=O)=O

• Molecular Weight:

  1808.99

• References & Citations:

  [1]Hemsén A, et al. Metabolism of Big endothelin-1 (1-38) and (22-38) in the human circulation in relation to production of endothelin-1 (1-21). Regul Pept. 1995 Feb 14;55(3):287-97. |[2]D'Orléans-Juste P, et al. Human big endothelin releases prostacyclin in vivo and in vitro through a phosphoramidon-sensitive conversion to endothelin-1. J Cardiovasc Pharmacol. 1991;17 Suppl 7:S251-5. |[3]Huneidi AH, et al. Endothelin-1 and big endothelin cause subarachnoid hemorrhage in the anesthetized rabbit. J Cardiovasc Pharmacol. 1991;17 Suppl 7:S492-5.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  124932-61-2