Endothelin 1 (swine, human)

• UNSPSC Description:

  Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB[1].

• Target Antigen:

  Endothelin Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/Endothelin_1_swine,_human.html

• Purity:

  99.12

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)|H2O : 0.99 mg/mL (adjust pH to 2 with TFA)

• Smiles:

  O=C([C@H]1NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@]2([H])NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@](CSSC2)([H])NC([C@@H](NC([C@H](CSSC1)N)=O)CO)=O)=O)CO)=O)CO)=O)CC(C)C)=O)CCSC)=O)CC(O)=O)=O)CCCCN)=O)CCC(O)=O)=O)=O)C(C)C)=O)CC3=CC=C(C=C3)O)=O)CC4=CC=CC=C4)=O)N[C@@H](CC5=CN=CN5)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC6=CNC7=CC=CC=C67)=O)=O)=O)=O)=O

• Molecular Weight:

  2491.90

• References & Citations:

  [1]Kowalczyk A, et al. The role of endothelin-1 and endothelin receptor antagonists in inflammatory response andsepsis. Arch Immunol Ther Exp (Warsz). 2015 Feb;63(1):41-52.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  117399-94-7