Products for Research Use Only
RegisterLogin

(5R) -5-Hydroxytriptolide

CAT: 0804-HY-107101-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-107101-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
(5R) -5-Hydroxytriptolide is an extracted compound from Tripterygium, and shows lower cell cytotoxicity and higher immunosuppressive activity. (5R) -5-Hydroxytriptolide can be used for study of rheumatoid arthritis[1].
CAS Number
583028-68-6
Product Name Alternative
PG 701; LLDT-8; 5α-Hydroxytriptolide
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/5r-5-hydroxytriptolide.html
Purity
99.67
Smiles
CC([C@@]12[C@H]([C@H]3[C@]4([C@@]5(C)CCC6=C(COC6=O)[C@]5(O)C[C@H]7[C@@]4(O7)[C@@H]2O)O3)O1)C
Molecular Formula
C20H24O7
Molecular Weight
376.40
References & Citations
[1]Guo S, et al. (5R) -5-Hydroxytriptolide (LLDT-8) induces substantial epigenetic mediated immune response network changes in fibroblast-like synoviocytes from rheumatoid arthritis patients. Sci Rep. 2019;9 (1) :11155. Published 2019 Aug 1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

PG-701

Hydroxytriptolide has been investigated for the treatment of Rheumatoid Arthritis.

CAS Number583028-68-6
PubChem CID10317383
IUPAC Name(1S,2S,4S,5S,7R,8R,9S,11S,13R)-8,13-dihydroxy-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-17-one
Molecular FormulaC20H24O7
Molecular Weight376.4
XLogP-0.9
Topological Polar Surface Area104
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count1
Heavy Atom Count27
Formal Charge0
Complexity866
SMILES
CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@]5(C[C@H]7[C@]4([C@@H]2O)O7)O)COC6=O)C
InChI
InChI=1S/C20H24O7/c1-8(2)18-12(26-18)13-20(27-13)16(3)5-4-9-10(7-24-14(9)21)17(16,23)6-11-19(20,25-11)15(18)22/h8,11-13,15,22-23H,4-7H2,1-3H3/t11-,12-,13-,15+,16-,17+,18-,19+,20+/m0/s1
InChIKey
OKRSVUYYCJPECG-LFGMFVMYSA-N
Chemical Structure
2D Structure
2D structure of PG-701
CAS: 583028-68-6
CID: 10317383
Formula: C20H24O7
MW: 376.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight376.4
XLogP3-0.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count1
Exact Mass376.15220310
Monoisotopic Mass376.15220310
Topological Polar Surface Area104 Ų
Heavy Atom Count27
Formal Charge0
Complexity866
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-167821(5R) -Platyphyllone
HY-12956B(5R) -Dinoprost
HY-N0894A(3R,5R) -Octahydrocurcumin
HY-1683825R (6S) -EET
HY-19282A-01(5R) -BW-4030W92
HY-17504D(3S,5R) -Rosuvastatin
HY-17504C(3R,5R) -Rosuvastatin
HY-114850A-01(5R) -Dinoprost (tromethamine)
HY-W1002207(5R) -Menthone-d3
HY-172253(5R) -Dimethylbenzene-camptothecin

Alternative Products

CatalogName
GTR19265994-01(5R) -5-Hydroxytriptolide
JH9170282,5-Pyrrolidinedimethanol, (2R,5R) -
TRC-D452905-10MG(5R,5’R)-Dihydroxy Lysinonorleucine
sc-238448(2R,5R) -2,5-Hexanediol
OR1077433(2R,5R) -2,5-Diphenylpyrrolidine
OR1041169-01(5R) -5-Phenyl-3-morpholinone
OR1041056-01(5R) -5- (Phenylmethyl) -3-morpholinone
OR302535(2R,5R) -2,5-Dimethylpyrrolidine
sc-497670(5R,5′R) -Dihydroxy Lysinonorleucine
D3600(2R, 5R) -2, 5-Diphenylpyrrolidine

Popular Products