2-Deoxy-D-glucose

2-Deoxy-D-glucose

• CAS Number: 154-17-6
• UNSPSC Description: 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1].
• Target Antigen: Apoptosis; Hexokinase; HSV
• Type: Natural Products
• Related Pathways: Anti-infection;Apoptosis;Metabolic Enzyme/Protease
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/2-Deoxy-D-glucose.html
• Solubility: H2O : ≥ 24 mg/mL
• Smiles: OC1O[C@@H]([C@@H](O)[C@H](O)C1)CO
• Molecular Weight: 164.157
• References & Citations: [1]Zhu Z, et al. 2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro. Cancer Res. 2005 Aug 1;65(15):7023-30.|[2]Ueyama A, et al. Nonradioisotope assay of glucose uptake activity in rat skeletal muscle using enzymatic measurement of 2-deoxyglucose 6-phosphate in vitro and in vivo. Biol Signals Recept. 2000 Sep-Oct;9(5):267-74.|[3]Miwa H, et al. Leukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose. Oncol Rep. 2013 May;29(5):2053-7.
• Shipping Conditions: Room Temperature
• Clinical Information: Phase 2