Citalopram-d3 (hydrochloride)

• UNSPSC Description:

  Citalopram-d3 hydrochloride is deuterated labeled Citalopram (HY-121203). Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active selective serotonin reuptake inhibitor (SSRI). Citalopram is an antidepressant and enhances serotoninergic neurotransmission[1][2][3].

• Target Antigen:

  Isotope-Labeled Compounds; Serotonin Transporter

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Neuronal Signaling;Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Neurological Disease

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CC1=CC2=C(C(C3=CC=C(F)C=C3)(CCCN(C)C([2H])([2H])[2H])OC2)C=C1.Cl

• Molecular Weight:

  363.87

• References & Citations:

  [1]Carlsson B, et al. Enantioselective analysis of citalopram and escitalopram in postmortem blood together with genotyping for CYP2D6 and CYP2C19. J Anal Toxicol. 2009;33(2):65-76. |[2]Laurent Sakka, et al. Assessment of citalopram and escitalopram on neuroblastoma cell lines. Cell toxicity and gene modulation. Oncotarget. 2017 Jun 27;8(26):42789-42807.|[3]Milne RJ, et al. Citalopram. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. Drugs. 1991;41(3):450-477. |[4]Zeng-Liang Jin, et al. Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function. Sci Rep. 2017 Aug 17;7(1):8631.|[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported