Moracin M (Standard)

• Description:

  Moracin M (Standard) is the analytical standard of Moracin M. This product is intended for research and analytical applications. Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent phosphodiesterase-4 (PDE4) inhibitor with IC50 values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity[1][2].

• UNSPSC:

  12352100

• Target:

  Autophagy; Endogenous Metabolite; NF-κB; Phosphodiesterase (PDE) ; Reference Standards

• Related Pathways:

  Autophagy; Metabolic Enzyme/Protease; NF-κB; Others

• Field of Research:

  Inflammation/Immunology

• Smiles:

  OC1=CC (C2=CC3=CC=C (O) C=C3O2) =CC (O) =C1

• Molecular Formula:

  C14H10O4

• Molecular Weight:

  242.23

• References & Citations:

  [1]Chen SK, et al. Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor. Bioorg Med Chem Lett. 2012 May 1;22 (9) :3261-4.|[2]Lee JH, et al. Moracin M inhibits airway inflammation by interrupting the JNK/c-Jun and NF-κB pathways in vitro and in vivo. Eur J Pharmacol. 2016;783:64-72.|[3]Guo F, et al. Moracin M inhibits lipopolysaccharide-induced inflammatory responses in nucleus pulposus cells via regulating PI3K/Akt/mTOR phosphorylation. Int Immunopharmacol. 2018 May;58:80-86.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  56317-21-6