Pifithrin-α (hydrobromide)

Pifithrin-α (hydrobromide)

• CAS Number: 63208-82-2
• UNSPSC Description: Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.
• Target Antigen: Apoptosis; Aryl Hydrocarbon Receptor; Ferroptosis; MDM-2/p53
• Type: Reference compound
• Related Pathways: Apoptosis;Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/Pifithrin-_alpha_-hydrobromide.html
• Solubility: DMSO : ≥ 50 mg/mL|H2O : 1.25 mg/mL (ultrasonic)
• Smiles: N=C1SC2=C(CCCC2)N1CC(C3=CC=C(C)C=C3)=O.[H]Br
• Molecular Weight: 367.30386
• References & Citations: [1]Yu W, et al. Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition. Int J Biol Sci. 2016 Jan 1;12(2):198-209.|[2]Hoagland MS, et al. The p53 Inhibitor Pifithrin-α Is a Potent Agonist of the Aryl Hydrocarbon Receptor. J Pharmacol Exp Ther. 2005 Aug;314(2):603-10.|[3]Kuang SQ, et al. FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. J Clin Invest. 2016 Mar 1;126(3):948-61.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported