BOS-172722

• UNSPSC Description:

  BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 11 nM and 63 nM for MPS1 (1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breast cancer[1].

• Target Antigen:

  Mps1

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/BOS-172722.html

• Purity:

  98.65

• Solubility:

  1M HCl : 65 mg/mL (ultrasonic;adjust pH to 2 with HCl)|DMSO : < 1 mg/mL

• Smiles:

  CC1=CC2=CN=C(NC3=CC=C(C4=NN=CN4C)C=C3OCC)N=C2C(NCC(C)(C)C)=N1

• Molecular Weight:

  446.55

• References & Citations:

  [1]ARYL SULFONOHYDRAZIDES. WO 2014037750 A1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Phase 1

• CAS Number:

  1578245-44-9