Z-VAD

CAT: 0804-HY-164388-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-164388-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Z-VAD is an irreversible, broad-spectrum pan-caspase inhibitor that can inhibit a variety of caspases including caspase-3, -6, -7, -8, -9, etc. (with a weaker inhibitory effect on caspase-2) . Z-VAD can block apoptosis signaling pathways, induce autophagy and necrosis in tumor cells, and has anti-angiogenic activity. Z-VAD can enhance the sensitivity of breast cancer and lung cancer cells to radiotherapy in vitro and in vivo, and prolong the growth delay of tumor xenograft models. Z-VAD is well tolerated and is mainly used in research related to cancer radiosensitization and cell death pathway regulation[1].

CAS Number

162852-62-2

UNSPSC

12352209

Target

Apoptosis; Autophagy; Caspase; Necroptosis

Type

Reference compound

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/z-vad.html

Concentration

10mM

Purity

99.82

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC(C[C@@H](C(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O)=O

Molecular Formula

C20H27N3O8

Molecular Weight

437.44

References & Citations

[1]Luigi Moretti, et al. Radiosensitization of solid tumors by Z-VAD, a pan-caspase inhibitor. Mol Cancer Ther. 2009 May;8 (5) :1270-9.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Caspase 3; Caspase 6; Caspase 7; Caspase 8; Caspase 9

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