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Polyadenylic acid (potassium)

CAT: 0804-HY-W416291-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W416291-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Polyadenylic acid potassium, also known as Poly (A), is enzymatically added to messenger RNA (mRNA) in eukaryotic cells to stabilize mRNAs. Poly (A) is used to evaluate binding on cationic liposomes doped with non-ionic nucleolipids. Poly (A) is used in small molecule mRNA targeted drug development to evaluate the binding of potential therapeutic agents such as the Isoquinoline group of alkaloids. Small molecules that could bind to this poly (A) tail could influence and possibly inhibit mRNA function and subsequent protein production in the cell leading to the development of new type of therapeutic agents.
CAS Number
26763-19-9
Product Name Alternative
Poly (A)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/polyadenylic-acid-potassium.html
Purity
90.00
Smiles
NC1=C2C(N([C@@H]3O[C@H](COP(O)(O[K])=O)[C@@H](O)[C@H]3O)C=N2)=NC=N1.[n]
Precautions
H302, H315, H319, H335
References & Citations
[1]Methods of biochemical analysis[M]. John Wiley & Sons, 2009.|[2]Cuomo F, Ceglie A, Colafemmina G, Germani R, Savelli G, Lopez F. Polyadenylic acid binding on cationic liposomes doped with the non-ionic nucleolipid Lauroyl Uridine. Colloids Surf B Biointerfaces. 2011 Feb 1;82 (2) :277-82.|[3]Giri P, Kumar GS. Molecular aspects of small molecules-poly (A) interaction: an approach to RNA based drug design. Curr Med Chem. 2009;16 (8) :965-87.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported

Chemical Information

Potassium [5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
CAS Number26763-19-9
PubChem CID53461514
IUPAC Namepotassium [5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
Molecular FormulaC10H13KN5O7P
Molecular Weight385.31
Topological Polar Surface Area189
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count11
Rotatable Bond Count4
Heavy Atom Count24
Formal Charge0
Complexity493
SMILES
C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)[O-])O)O)N.[K+]
InChI
InChI=1S/C10H14N5O7P.K/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20;/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20);/q;+1/p-1
InChIKey
WADAUMZGCLRVDM-UHFFFAOYSA-M
Chemical Structure
2D Structure
2D structure of Potassium [5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
CAS: 26763-19-9
CID: 53461514
Formula: C10H13KN5O7P
MW: 385.31
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight385.31
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count11
Rotatable Bond Count4
Exact Mass385.01896625
Monoisotopic Mass385.01896625
Topological Polar Surface Area189 Ų
Heavy Atom Count24
Formal Charge0
Complexity493
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count4
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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