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Orotic acid (potassium)

CAT: 0804-HY-N0157C-01Size: 5 gDry Ice: NoHazardous: No
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CAT#:0804-HY-N0157C-01Size:5 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Orotic acid potassium (Vitamin B13 potassium) is a precursor of pyrimidine bases and is involved in the synthesis of DNA and RNA. Orotic acid potassium stimulates the growth of animals, plants and microorganisms, participates in carbohydrate metabolism, and is necessary for the growth and life activities of organisms. Orotic acid potassium is a measurement indicator in routine newborn screening for urea cycle abnormalities. Orotic acid potassium can cause hepatic steatosis and hepatomegaly in rats[1][2][3][4].
CAS Number
24598-73-0
Product Name Alternative
6-Carboxyuracil (potassium) ; Vitamin B13 (potassium)
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis; Endogenous Metabolite
Type
Biochemical Assay Reagents
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/orotic-acid-potassium.html
Purity
99.51
Solubility
H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C(NC1=O)=CC(N1)=O)O[K]
Molecular Formula
C5H3KN2O4
Molecular Weight
194.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Löffler M, et, al. Orotate (orotic acid) : An essential and versatile molecule. Nucleosides Nucleotides Nucleic Acids.|[2]Staretz-Chacham O, et, al. The role of orotic acid measurement in routine newborn screening for urea cycle disorders. J Inherit Metab Dis. 2020 Nov 15.|[3]Durschlag RP, et, al. Orotic acid-induced metabolic changes in the rat. J Nutr. 1980 Apr;110 (4) :816-21.|[4]Kochkin, et al. "Orotic acid and its derivatives. Preparation, properties, and uses." Pharmaceutical Chemistry Journal 11.8 (1977) : 1155-1160.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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