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YM022

CAT: 0804-HY-103355-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103355-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YM022 is a highly potent, selective and orally active gastrin/cholecystokinin (CCK) -B receptor (CCK-BR) antagonist. YM022 shows the Ki values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively[1]. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo[3].
CAS Number
145084-28-2
UNSPSC
12352005
Hazard Statement
H301
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ym022.html
Purity
99.87
Smiles
O=C(NC1=CC=CC(C)=C1)N[C@H]2C(N(CC(C3=CC=CC=C3C)=O)C4=CC=CC=C4C(C5=CC=CC=C5)=N2)=O
Molecular Formula
C32H28N4O3
Molecular Weight
516.59
Precautions
H301
References & Citations
[1]Nishida A, et al. Pharmacological profile of (R) -1-[2,3-dihydro-1- (2'-methylphenacyl) -2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl]-3- (3-methylphenyl) urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo.J Pharmacol Exp Ther. 1994 May;269 (2) :725-31.|[2]Kitano M, et al. Long-lasting cholecystokinin (2) receptor blockade after a single subcutaneous injection of YF476 or YM022.Br J Pharmacol. 2000 Jun;130 (3) :699-705.|[3]Beinborn M, et al. Small synthetic ligands of the cholecystokinin-B/gastrin receptor can mimic the function of endogenous peptide hormones.Yale J Biol Med. 1998 May-Aug;71 (3-4) :337-46.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR1; CCR2

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CatalogName
C04789-1mgYM022

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