Concanamycin B

• Description :

  Concanamycin B is a macrolide antibiotic, which can inhibit the cavitation type H+-ATPases, and the IC50 value is 5 nM[1].

• Product Name Alternative :

  MCH 210

• UNSPSC :

  12352005

• Target :

  Antibiotic; Proton Pump

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/concanamycin-b.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1O[C@H]([C@@H](C)[C@@H](O)[C@@H]([C@@]2(O)C[C@@H](O[C@H]3C[C@H]([C@@H]([C@@H](C)O3)OC(N)=O)O)[C@H](C)[C@@H](/C=C/C)O2)C)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C(C)\C=C1/O

• Molecular Formula :

  C44H71NO14

• Molecular Weight :

  838.03

• References & Citations :

  [1]Yilla M, et al. Involvement of the vacuolar H (+) -ATPases in the secretory pathway of HepG2 cells. J Biol Chem. 1993 Sep 5;268 (25) :19092-100. PMID: 8395529.|[2]Woo JT, et al. Inhibition of the acidification of endosomes and lysosomes by the antibiotic concanamycin B in macrophage J774. Eur J Biochem. 1992 Jul 1;207 (1) :383-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Macrolide

• CAS Number :

  [81552-33-2]