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Concanamycin A

CAT: 0804-HY-N1724-01Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1724-01Size:25 µg
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Description
Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research[1]-[5].
CAS Number
80890-47-7
Product Name Alternative
Antibiotic X 4357B; Folimycin; X 4357B
UNSPSC
12352005
Hazard Statement
H300, H310, H319, H330
Target
Antibiotic; Bacterial; Proton Pump
Type
Natural Products
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/concanamycin-a.html
Purity
99.84
Solubility
DMSO : ≥ 10 mg/mL
Smiles
C[C@H]([C@@](C[C@H]1O[C@@](O[C@H](C)[C@H]2OC(N)=O)([H])C[C@H]2O)(O[C@H](/C=C/C)[C@H]1C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@H]([C@@H](O)[C@H]3CC)C)=O)([H])[C@H](/C=C/C=C(C[C@H]([C@@H]3O)C)/C)OC)C
Molecular Formula
C46H75NO14
Molecular Weight
866.09
Precautions
H300, H310, H319, H330
References & Citations
[1]Togashi K, et al. Concanamycin A, a vacuolar type H (+) -ATPase inhibitor, induces cell death in activated CD8 (+) CTL. Cytotechnology. 1997 Nov;25 (1-3) :127-35.|[2]Eswarappa SM, et al. Folimycin (concanamycin A) inhibits LPS-induced nitric oxide production and reduces surface localization of TLR4 in murine macrophages. Innate Immun. 2008 Feb;14 (1) :13-24.|[3]Hines IN, et al. Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα) -deficient mice. Biol Res. 2018 Feb 15;51 (1) :5.|[4]Woo JT, et al. Isolation, characterization and biological activities of concanamycins as inhibitors of lysosomal acidification. J Antibiot (Tokyo) . 1992 Jul;45 (7) :1108-16.|[5]Vaněk, Z., et al. Immunomodulators isolated from microorganisms. Folia Microbiol. 1991. 36:99–111.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Macrolide

Alternative Products

CatalogName
A8633-.025Concanamycin A

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