Concanamycin A

• Description:

  Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research[1]-[5].

• Product Name Alternative:

  Antibiotic X 4357B; Folimycin; X 4357B

• UNSPSC:

  12352005

• Hazard Statement:

  H300, H310, H319, H330

• Target:

  Antibiotic; Bacterial; Proton Pump

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/concanamycin-a.html

• Purity:

  99.84

• Solubility:

  DMSO : ≥ 10 mg/mL

• Smiles:

  C[C@H]([C@@](C[C@H]1O[C@@](O[C@H](C)[C@H]2OC(N)=O)([H])C[C@H]2O)(O[C@H](/C=C/C)[C@H]1C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@H]([C@@H](O)[C@H]3CC)C)=O)([H])[C@H](/C=C/C=C(C[C@H]([C@@H]3O)C)/C)OC)C

• Molecular Formula:

  C46H75NO14

• Molecular Weight:

  866.09

• Precautions:

  H300, H310, H319, H330

• References & Citations:

  [1]Togashi K, et al. Concanamycin A, a vacuolar type H (+) -ATPase inhibitor, induces cell death in activated CD8 (+) CTL. Cytotechnology. 1997 Nov;25 (1-3) :127-35.|[2]Eswarappa SM, et al. Folimycin (concanamycin A) inhibits LPS-induced nitric oxide production and reduces surface localization of TLR4 in murine macrophages. Innate Immun. 2008 Feb;14 (1) :13-24.|[3]Hines IN, et al. Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα) -deficient mice. Biol Res. 2018 Feb 15;51 (1) :5.|[4]Woo JT, et al. Isolation, characterization and biological activities of concanamycins as inhibitors of lysosomal acidification. J Antibiot (Tokyo) . 1992 Jul;45 (7) :1108-16.|[5]Vaněk, Z., et al. Immunomodulators isolated from microorganisms. Folia Microbiol. 1991. 36:99–111.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Macrolide

• CAS Number:

  [80890-47-7]