RNase L-IN-1 (trihydrochloride)

RNase L-IN-1 (trihydrochloride)

• UNSPSC Description: RNase L-IN-1 (compound 17a) trihydrochloride is an inhibitor of RNase L or ribonuclease L. RNase L degrades RNA to prevent viral replication and mediates innate immune responses and inflammation[1].
• Target Antigen: DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/rnase-l-in-1-trihydrochloride.html
• Solubility: DMSO : 200 mg/mL (ultrasonic)
• Smiles: O=C1/C(SC(NC2=CC(F)=CC=C2)=C1C(NCCN)=O)=C\C3=C(C)C(C(NCCN(CC)CC)=O)=C(C)N3.[H]Cl.[H]Cl.[H]Cl
• Molecular Weight: 652.05
• References & Citations: [1]Hwang J, et al. Rational design and evaluation of 2-((pyrrol-2-yl)methylene)thiophen-4-ones as RNase L inhibitors. Eur J Med Chem. 2023 Aug 5;256:115439.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported