RNase L-IN-1

RNase L-IN-1

• UNSPSC Description: RNase L-IN-1 (compound 17a) is an inhibitor of RNase L, or Ribonuclease L. RNase L degrades RNAs to prevent viral replication, and mediates the innate immune responses and inflammation[1].
• Target Antigen: DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/rnase-l-in-1.html
• Solubility: DMSO : 8.33 mg/mL (ultrasonic;warming;heat to 80°C)
• Smiles: O=C1/C(SC(NC2=CC(F)=CC=C2)=C1C(NCCN)=O)=C\C3=C(C)C(C(NCCN(CC)CC)=O)=C(C)N3
• Molecular Weight: 542.67
• References & Citations: [1]Hwang J, et al. Rational design and evaluation of 2-((pyrrol-2-yl)methylene)thiophen-4-ones as RNase L inhibitors. Eur J Med Chem. 2023 Aug 5;256:115439.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported