RNase L-IN-1 (trihydrochloride)

• UNSPSC Description:

  RNase L-IN-1 (compound 17a) trihydrochloride is an inhibitor of RNase L or ribonuclease L. RNase L degrades RNA to prevent viral replication and mediates innate immune responses and inflammation[1].

• Target Antigen:

  DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/rnase-l-in-1-trihydrochloride.html

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  O=C1/C(SC(NC2=CC(F)=CC=C2)=C1C(NCCN)=O)=C\C3=C(C)C(C(NCCN(CC)CC)=O)=C(C)N3.[H]Cl.[H]Cl.[H]Cl

• Molecular Weight:

  652.05

• References & Citations:

  [1]Hwang J, et al. Rational design and evaluation of 2-((pyrrol-2-yl)methylene)thiophen-4-ones as RNase L inhibitors. Eur J Med Chem. 2023 Aug 5;256:115439.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported