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Pomisartan

CAT: 0804-HY-106123Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-106123Size:1 Each
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Description
Pomisartan is an orally active angiotensin II receptor type AT1 antagonist (IC50=0.26 μM) . Pomisartan works by inhibiting the binding of angiotensin II to the AT1 receptor, thereby blocking the vasoconstriction and aldosterone release caused by this interaction. Pomisartan results in a blood pressure-lowering effect[1].
CAS Number
144702-17-0
UNSPSC
12352005
Target
Angiotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pomisartan.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C2=CC=C(CN3C4=CC(C5=CN(CCCC6)C6=N5)=CC(C)=C4N=C3CC)C=C2)C=CC=C1)O
Molecular Formula
C31H30N4O2
Molecular Weight
490.60
References & Citations
[1]Krovat EM, et al. Non-peptide angiotensin II receptor antagonists: chemical feature based pharmacophore identification. J Med Chem. 2003 Feb 27;46 (5) :716-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
T28437-01Pomisartan
T28437L-01Pomisartan 2HCl

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