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PF-1367550

CAT: 0804-HY-167884Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-167884Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-1367550 is a pan-JAK inhibitor. PF-1367550 can decrease the levels of release of CXCL9, CXCL10 and CXCL11 from primary airway epithelial cells[1].
CAS Number
319461-60-4
UNSPSC
12352005
Target
JAK
Type
Natural Products
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pf-1367550.html
Smiles
OC1=CC(CC)=C(C2=CC3=C(C(C4=NC5=C(N4)C=CC=C5)=NN3)C=C2)C=C1
Molecular Formula
C22H18N4O
Molecular Weight
354.40
References & Citations
[1]Fenwick PS, et, al. Effect of JAK Inhibitors on Release of CXCL9, CXCL10 and CXCL11 from Human Airway Epithelial Cells. PLoS One. 2015 Jun 19;10 (6) :e0128757.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

Chemical Information

PF-1367550
CAS Number319461-60-4
PubChem CID135567293
IUPAC Name4-[3-(1H-benzimidazol-2-yl)-1H-indazol-6-yl]-3-ethylphenol
Molecular FormulaC22H18N4O
Molecular Weight354.4
XLogP4.9
Topological Polar Surface Area77.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity517
SMILES
CCC1=C(C=CC(=C1)O)C2=CC3=C(C=C2)C(=NN3)C4=NC5=CC=CC=C5N4
InChI
InChI=1S/C22H18N4O/c1-2-13-11-15(27)8-10-16(13)14-7-9-17-20(12-14)25-26-21(17)22-23-18-5-3-4-6-19(18)24-22/h3-12,27H,2H2,1H3,(H,23,24)(H,25,26)
InChIKey
CSLGOZXFBHTYAA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of PF-1367550
CAS: 319461-60-4
CID: 135567293
Formula: C22H18N4O
MW: 354.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight354.4
XLogP34.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass354.14806121
Monoisotopic Mass354.14806121
Topological Polar Surface Area77.6 Ų
Heavy Atom Count27
Formal Charge0
Complexity517
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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