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(±) -Nornicotine-d7

CAT: 0804-HY-W002112S1Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W002112S1Size:1 Each
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Description
(±) -Nornicotine-d7 is the deuterium labeled (±) -Nornicotine. (±) -Nornicotine is a major metabolite of Nicotine. (±) -Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±) -Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±) -Nornicotine supports self-administration behavior. (±) -Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia[1][2][3][4][5].
Product Name Alternative
Nornicotine-d7
UNSPSC
12352005
Target
Drug Metabolite; Endogenous Metabolite; Isotope-Labeled Compounds; nAChR; β-catenin
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others; Stem Cell/Wnt
Field of Research
Neurological Disease; Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
[2H]C1=NC([2H])=C(C([2H])=C1[2H])C2NCCC2([2H])[2H]
Molecular Formula
C9H6D6N2
Molecular Weight
154.24
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Papke RL, et al. The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery. J Neurochem. 2007 Apr;101 (1) :160-7. |[3]Gagat M, et al. Nornicotine impairs endothelial cell-cell adherens junction complexes in EA.hy926 cell line via structural reorganization of F-actin. Folia Histochem Cytobiol. 2013;51 (3) :179-92.|[4]Bardo MT, et al. Nornicotine is self-administered intravenously by rats. Psychopharmacology (Berl) . 1999 Oct;146 (3) :290-6.|[5]Hoffman AC, et al. Abuse potential of non-nicotine tobacco smoke components: acetaldehyde, nornicotine, cotinine, and anabasine. Nicotine Tob Res. 2013 Mar;15 (3) :622-32.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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