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(±) -Nornicotine-d4

CAT: 0804-HY-W002112S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W002112S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(±) -Nornicotine-d4 is the deuterium labeled (±) -Nornicotine. (±) -Nornicotine is a major metabolite of Nicotine. (±) -Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±) -Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±) -Nornicotine supports self-administration behavior. (±) -Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia[1][2][3][4][5].
CAS Number
66148-18-3
Product Name Alternative
Nornicotine-d4
UNSPSC
12352005
Hazard Statement
H301, H311, H315, H319, H331, H335
Target
Drug Metabolite; Endogenous Metabolite; Isotope-Labeled Compounds; nAChR; β-catenin
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others; Stem Cell/Wnt
Field of Research
Neurological Disease; Cardiovascular Disease
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[2H]C1=C(C2NCCC2)C([2H])=C([2H])C([2H])=N1
Molecular Formula
C9H8D4N2
Molecular Weight
152.23
Precautions
H301, H311, H315, H319, H331, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Hoffman AC, et al. Abuse potential of non-nicotine tobacco smoke components: acetaldehyde, nornicotine, cotinine, and anabasine. Nicotine Tob Res. 2013 Mar;15 (3) :622-32.|[3]Papke RL, et al. The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery. J Neurochem. 2007 Apr;101 (1) :160-7.|[4]Gagat M, et al. Nornicotine impairs endothelial cell-cell adherens junction complexes in EA.hy926 cell line via structural reorganization of F-actin. Folia Histochem Cytobiol. 2013;51 (3) :179-92.|[5]Bardo MT, et al. Nornicotine is self-administered intravenously by rats. Psychopharmacology (Berl) . 1999 Oct;146 (3) :290-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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