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SEC inhibitor KL-1

CAT: 0804-HY-122720-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122720-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SEC inhibitor KL-1 (KL-1) is a peptide-like lead compound that is an effective selective SEC inhibitor. SEC inhibitor KL-1 promotes apoptosis and has anti-tumor activity. SEC inhibitor KL-1 doses dependently inhibits the AFF4-CCNT1 interaction, with a Ki value of 3.48 μM[1][2].
CAS Number
900308-84-1
Product Name Alternative
KL-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sec-inhibitor-kl-1.html
Purity
99.58
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
O=C(/C(O)=C/C(C1=CC=CC(OC)=C1)=O)NC2=CC(Cl)=CC=C2C
Molecular Formula
C18H16ClNO4
Molecular Weight
345.78
Precautions
H302, H315, H319, H335
References & Citations
[1]Liang K, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced CancerTherapy. Cell. 2018 Oct 18;175 (3) :766-779.|[2]Hiroaki Katagi, et al. Therapeutic targeting of transcriptional elongation in diffuse intrinsic pontine glioma. Neuro Oncol. 2021 Aug 2;23 (8) :1348-1359.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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