KL-50

• Description :

  KL-50 is a selective toxin toward tumors that lack the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O6-alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR) . KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT[1][2].

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/kl-50.html

• Purity :

  99.82

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C(N=CN12)=C2N=NN(CCF)C1=O)N

• Molecular Formula :

  C7H7FN6O2

• Molecular Weight :

  226.17

• References & Citations :

  [1]Huseman ED, et al. Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers. J Am Chem Soc. 2024 Jul 10;146 (27) :18241-18252.|[2]HERZON Seth, et al. Preparation of imidazotetrazine compounds and methods for treating cancers that are MGMT deficient regardless of MMR status. WO2023049806. 2022 September 22.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1161826-19-2]