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SOCS-3 Polyclonal Antibody

CAT: 0749-ABP60458-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP60458-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SOCS3 encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of SOCS3 is induced by various cytokines, including IL6, IL10, and interferon (IFN) -gamma. The protein encoded by SOCS3 can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of SOCS3 suggested the roles of SOCS3 in the negative regulation of fetal liver hematopoiesis, and placental development. SOCS3 (Suppressor Of Cytokine Signaling 3) is a Protein Coding gene. Diseases associated with SOCS3 include Overnutrition and Atopic Dermatitis. Among its related pathways are Type II interferon signaling (IFNG) and Adipocytokine signaling pathway.
Description
Rabbit Anti-SOCS-3 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Suppressor of cytokine signaling 3; SOCS-3; Cytokine-inducible SH2 protein 3; CIS-3; STAT-induced STAT inhibitor 3; SSI-3
Gene ID
9021
Accession Number
O14543
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from part region of human SOCS-3 protein at amino acid sequence of 20-70
Clonality
Polyclonal
Tag
SOCS-3
Applications
WB, IHC, IF
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of SOCS-3
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC:1:50-300; IF 1:50-200
Other Product Names
Suppressor of cytokine signaling 3; SOCS-3; Cytokine-inducible SH2 protein 3; CIS-3; STAT-induced STAT inhibitor 3; SSI-3
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/O14543
Isotype
Rabbit IgG

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