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PTN21 Polyclonal Antibody

CAT: 0749-ABP60032-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP60032-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The Protein Tyrosine Phosphatase, Non-Receptor Type 21 encoded by PTPN21 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4. , ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.
Description
Rabbit Anti-PTN21 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Tyrosine-protein phosphatase non-receptor type 21; Protein-tyrosine phosphatase D1
Gene ID
11099
Accession Number
Q16825
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from part region of human PTN21 protein
Clonality
Polyclonal
Tag
PTN21
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
129kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of PTN21 protein
Observed Molecular Weight
129
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
Tyrosine-protein phosphatase non-receptor type 21; Protein-tyrosine phosphatase D1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q16825
Isotype
Rabbit IgG

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