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POLH Polyclonal Antibody

CAT: 0749-ABP59967-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP59967-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
POLH encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.
Description
Rabbit Anti-POLH Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
DNA polymerase eta; RAD30 homolog A; Xeroderma pigmentosum variant type protein
Gene ID
5429
Accession Number
Q9Y253
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from part region of human POLH protein
Clonality
Polyclonal
Tag
POLH
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
78kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of POLH protein
Observed Molecular Weight
78
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
DNA polymerase eta; RAD30 homolog A; Xeroderma pigmentosum variant type protein
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q9Y253
Isotype
Rabbit IgG

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