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DNA pol ζ Polyclonal Antibody

CAT: 0749-ABP56039-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP56039-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. These exonucleases include the family of DNA polymerases. DNA pol α, β, δ, and e are involved in DNA replication and repair. DNA pol δ and DNA pol e are multisubunit enzymes, with DNA pol δ consisting of two subunits p125, which interacts with the sliding DNA clamp protein PCNA, and p50. The nuclear-encoded DNA pol γ is the only DNA polymerase required for the replication of the mitochondrial DNA. DNA pol Ω is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis. DNA pol œ is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks.
Description
Rabbit Anti-DNA pol ζ Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
REV3L; POLZ; REV3; DNA polymerase zeta catalytic subunit; Protein reversionless 3-like; REV3-like; hREV3
Gene ID
5980
Accession Number
O60673
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the N-terminal region of human DNA pol ζ at AA range: 200-280
Clonality
Polyclonal
Tag
DNA polymerase zeta catalytic subunit
Applications
IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
DNA pol ζ Polyclonal Antibody detects endogenous levels of DNA pol ζ protein.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Other Product Names
REV3L; POLZ; REV3; DNA polymerase zeta catalytic subunit; Protein reversionless 3-like; REV3-like; hREV3
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/O60673
Isotype
Rabbit IgG

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