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MRP5 Polyclonal Antibody

CAT: 0749-ABP59327-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP59327-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ABCC5 (ATP Binding Cassette Subfamily C Member 5) is a Protein Coding gene. Diseases associated with ABCC5 include Lymphoblastic Leukemia. Among its related pathways are Glycosaminoglycan metabolism and CDK-mediated phosphorylation and removal of Cdc6. The protein encoded by ABCC5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9- (2-phosphonylmethoxyethyl) adenine.
Description
Rabbit Anti-MRP5 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Multidrug resistance-associated protein 5; ATP-binding cassette sub-family C member 5; Multi-specific organic anion transporter C; MOAT-C
Gene ID
10057
Accession Number
O15440
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from part region of human MRP5 protein at amino acid sequence of 470-550
Clonality
Polyclonal
Tag
MRP5
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
158kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of MRP5 protein
Observed Molecular Weight
158
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
Multidrug resistance-associated protein 5; ATP-binding cassette sub-family C member 5; Multi-specific organic anion transporter C; MOAT-C
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/O15440
Isotype
Rabbit IgG

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