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NOS1-IN-1

CAT: 0804-HY-130452-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-130452-01Size:500 µg
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Description
NOS1-IN-1 is a selective and cell-permeable nNOS inhibitor with a Ki of 120 nM. NOS1-IN-1 exhibits 2617-fold and 325-fold selectivity over eNOS (Ki=39 μM) and iNOS (Ki=325 μM), respectively[1]. NOS1-IN-1 can be used for the research of neurological disease, including cerebral palsy (CP) [2].
CAS Number
357965-99-2
UNSPSC
12352211
Hazard Statement
H315-H319-H335
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nos1-in-1.html
Purity
95.0
Solubility
10 mM in DMSO|H2O : ≥ 50mg/mL
Smiles
N=C(N[N+]([O-])=O)NCCC[C@H](N)CNCCN.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Molecular Formula
C14H24F9N7O8
Molecular Weight
589.37
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]J M Hah, et al. Reduced amide bond peptidomimetics. (4S) -N- (4-amino-5-[aminoakyl]aminopentyl) -N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. J Med Chem. 2001 Aug 2;44 (16) :2667-70.|[2]Haitao Ji, et al. Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Ann Neurol. 2009 Feb;65 (2) :209-17.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NNOS

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