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(Rac) -Rotigotine

CAT: 0804-HY-15394A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15394A-01Size:5 mg
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Description
(Rac) -Rotigotine (N-0437) is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.
CAS Number
92206-54-7
Product Name Alternative
N-0437
UNSPSC
12352005
Hazard Statement
H336-H361-H362
Target
5-HT Receptor; Adrenergic Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rac-rotigotine.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
OC1=C2CCC(CC2=CC=C1)N(CCC3=CC=CS3)CCC
Molecular Formula
C19H25NOS
Molecular Weight
315.47
Precautions
P260-P261-P263-P264-P270-P271-P280-P304+P340-P403+P233-P405-P501
References & Citations
[1]Wood M, et al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172 (4) :1124-35.|[2]Scheller D, et al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379 (1) :73-86.|[3]Fenu S, et al. In vivo dopamine agonist properties of rotigotine: Role of D1 and D2 receptors. Eur J Pharmacol. 2016 Oct 5;788:183-91.|[4]Radad K, et al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP+ and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014;52 (2) :179-86.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT1 Receptor

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