Rotigotine

CAT: 0804-HY-75502-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-75502-01Size:5 mg
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Description
Rotigotine is a potent dopamine receptor agonist with Ki values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. Rotigotine can be used for parkinson's disease (PD) research[1][2][3][4].
CAS Number
[99755-59-6]
Product Name Alternative
N-0923; (-) -N 0437
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
5-HT Receptor; Adrenergic Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/rotigotine.html
Purity
99.99
Solubility
DMSO : ≥ 50 mg/mL
Smiles
CCCN(CCC1=CC=CS1)[C@H]2CCC3=C(C=CC=C3O)C2
Molecular Formula
C19H25NOS
Molecular Weight
315.47
Precautions
H302, H315, H319
References & Citations
[1]Wood M, et, al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172 (4) :1124-35.|[2]Radad K, et, al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP⁺ and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014;52 (2) :179-86. |[3]Bertaina-Anglade V, et, al. Antidepressant properties of rotigotine in experimental models of depression. Eur J Pharmacol. 2006 Oct 24;548 (1-3) :106-14.|[4]Scheller D, et, al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379 (1) :73-86.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT1 Receptor; D1 Receptor; D2 Receptor; D3 Receptor; D4 Receptor; D5 Receptor; mLAG-3; MUC3
Citation 01
BioRxiv. 2025 Aug 12:2025.08.08.668522.|Clin Chem. 2019 Dec;65 (12) :1522-1531. |Acta Pharmacol Sin. 2025 May 6.

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