Rotigotine

• Description :

  Rotigotine is a potent dopamine receptor agonist with Ki values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. Rotigotine can be used for parkinson's disease (PD) research[1][2][3][4].

• Product Name Alternative :

  N-0923; (-) -N 0437

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  5-HT Receptor; Adrenergic Receptor; Dopamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/rotigotine.html

• Purity :

  99.99

• Solubility :

  DMSO : ≥ 50 mg/mL

• Smiles :

  CCCN(CCC1=CC=CS1)[C@H]2CCC3=C(C=CC=C3O)C2

• Molecular Formula :

  C19H25NOS

• Molecular Weight :

  315.47

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Wood M, et, al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172 (4) :1124-35.|[2]Radad K, et, al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP⁺ and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014;52 (2) :179-86. |[3]Bertaina-Anglade V, et, al. Antidepressant properties of rotigotine in experimental models of depression. Eur J Pharmacol. 2006 Oct 24;548 (1-3) :106-14.|[4]Scheller D, et, al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379 (1) :73-86.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  5-HT1 Receptor; D1 Receptor; D2 Receptor; D3 Receptor; D4 Receptor; D5 Receptor; mLAG-3; MUC3

• Citation 01 :

  BioRxiv. 2025 Aug 12:2025.08.08.668522.|Clin Chem. 2019 Dec;65 (12) :1522-1531. |Acta Pharmacol Sin. 2025 May 6.

• CAS Number :

  [99755-59-6]