Rotigotine (Standard)

Rotigotine (Standard)

• CAS Number: 99755-59-6
• UNSPSC Description: Rotigotine (Standard) is the analytical standard of Rotigotine. This product is intended for research and analytical applications. Rotigotine is a potent dopamine receptor agonist with Ki values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. Rotigotine can be used for parkinson's disease (PD) research[1][2][3][4].
• Target Antigen: 5-HT Receptor; Adrenergic Receptor; Dopamine Receptor
• Type: Reference Standards
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Field of Research: Neurological Disease; Endocrinology
• Assay Protocol: https://www.medchemexpress.com/rotigotine-standard.html
• Smiles: CCCN(CCC1=CC=CS1)[C@H]2CCC3=C(C=CC=C3O)C2
• Molecular Weight: 315.47
• References & Citations: [1]Wood M, et, al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172(4):1124-35.|[2]Radad K, et, al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP⁺ and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014;52(2):179-86. |[3]Bertaina-Anglade V, et, al. Antidepressant properties of rotigotine in experimental models of depression. Eur J Pharmacol. 2006 Oct 24;548(1-3):106-14.|[4]Scheller D, et, al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86.
• Shipping Conditions: Room temperature