ACAP1 (phospho Ser554) Polyclonal Antibody

CAT: 0749-ABP57096-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP57096-01Size:30 µL
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Background
ACAP1, also designated Centaurin-β 1 (CENTB1 or Cnt-β1), is a member of the ADP ribosylation factor family of ARF6 GTPase-activating proteins (GAP) . GAPs are important regulators of Arf function by controlling the return of ARF to its inactive state. ACAP1 is related to AGAP1 and ASAP1, and all three proteins are similarly expressed in fibroblast cells such as NIH/3T3. Internalization and recycling of integrin receptors is important in cell adhesion and migration modulation, and once inside a cell, proteins and membranes are transported to the endosome where they are sorted for recycling or degradation. ACAP1 promotes cargo sorting by associating directly to recycling cargo proteins. Preventing this interaction inhibits protein recycling. ACAP1 binds transferrin receptors, promoting their transport to the plasma membrane from the endosome. Akt induced phosphorylation of ACAP1 at Ser 554 regulates ACAP1 interaction to integrin in endosomes, and downregulation of Akt or ACAP1 may inhibit cell migration on Fibronectin.
Description
Rabbit Anti-ACAP1 (phospho Ser554) Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
ACAP1; CENTB1; KIAA0050; Arf-GAP with coiled-coil; ANK repeat and PH domain-containing protein 1; Centaurin-beta-1; Cnt-b1
Gene ID
9744
Accession Number
Q15027
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from human ACAP1 around the phosphorylation site of S554
Clonality
Polyclonal
Tag
Arf-GAP with coiled-coil ANK repeat and PH domain-containing protein 1
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Phospho-ACAP1 (S554) Polyclonal Antibody detects endogenous levels of ACAP1 protein only when phosphorylated at S554.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; WB 1:500-2000; IHC 1:100-1:300; ELISA 1:10000-40000; IF 1:50-200
Other Product Names
ACAP1; CENTB1; KIAA0050; Arf-GAP with coiled-coil; ANK repeat and PH domain-containing protein 1; Centaurin-beta-1; Cnt-b1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q15027
Isotype
Rabbit IgG

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