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Econazole

CAT: 0804-HY-B0885-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0885-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Econazole ((±) -Econazol) is an orally active imidazole antifungal agent, as well as a cytochrome P-450 inhibitor and a blocker of calcium and manganese ion uptake. Econazole is active against a variety of fungi and some Gram-positive bacteria, but has no significant activity against Gram-negative bacteria. Econazole can inhibit the synthesis of prostaglandins and can also induce liver damage[1][2][3][4][5].
CAS Number
27220-47-9
Product Name Alternative
(±) -Econazol
UNSPSC
12352005
Hazard Statement
H302
Target
Bacterial; Calcium Channel; Cytochrome P450; Fungal
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Econazole.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(C(OCC2=CC=C(Cl)C=C2)CN3C=CN=C3)C(Cl)=C1
Molecular Formula
C18H15Cl3N2O
Molecular Weight
381.68
Precautions
H302
References & Citations
[1]Mason MJ, et al. Inhibition of Ca2+ transport pathways in thymic lymphocytes by econazole, miconazole, and SKF 96365. Am J Physiol. 1993 Mar;264 (3 Pt 1) :C654-62.|[2]Heel RC, et al. Econazole: a review of its antifungal activity and therapeutic efficacy. Drugs. 1978 Sep;16 (3) :177-201.|[3]Hill K, et al. Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole. Naunyn Schmiedebergs Arch Pharmacol. 2004 Oct;370 (4) :227-37.|[4]Köfeler HC, et al. Effect of cytochrome P-450 inhibitors econazole, bifonazole and clotrimazole on prostanoid formation. Br J Pharmacol. 2000 Jul;130 (6) :1241-6.|[5]Liu CF, et al. Antioxidative natural product protect against econazole-induced liver injuries. Toxicology. 2004 Mar 1;196 (1-2) :87-93.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Adv Sci (Weinh) . 2024 Jul 23:e2310126.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|BMC Cancer. 2025 May 28;25 (1) :956.|Oxid Med Cell Longev. 2019 Aug 5:2019:8265958.|Anal Biochem. 2019 Dec 15;587:113463.

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