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Econazole-d6

CAT: 0804-HY-B0885SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0885SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Econazole-d6 ((±) -Econazol-d6) is the deuterium labeled Econazole. Econazole is an orally active imidazole antifungal agent, as well as a cytochrome P-450 inhibitor and a blocker of calcium and manganese ion uptake. Econazole is active against a variety of fungi and some Gram-positive bacteria, but has no significant activity against Gram-negative bacteria. Econazole can inhibit the synthesis of prostaglandins and can also induce liver damage[1][2][3][4][5].
CAS Number
2469273-40-1
Product Name Alternative
(±) -Econazol-d6
UNSPSC
12352005
Target
Bacterial; Calcium Channel; Cytochrome P450; Fungal; Isotope-Labeled Compounds
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Infection; Metabolic Disease
Smiles
ClC(C([2H])=C1[2H])=C([2H])C([2H])=C1C([2H])([2H])OC(C2=C(C=C(C=C2)Cl)Cl)CN3C=CN=C3
Molecular Formula
C18H9D6Cl3N2O
Molecular Weight
387.72
References & Citations
[1]Köfeler HC, et al. Effect of cytochrome P-450 inhibitors econazole, bifonazole and clotrimazole on prostanoid formation. Br J Pharmacol. 2000 Jul;130 (6) :1241-6. |[2]Mason MJ, et al. Inhibition of Ca2+ transport pathways in thymic lymphocytes by econazole, miconazole, and SKF 96365. Am J Physiol. 1993 Mar;264 (3 Pt 1) :C654-62.|[3]Hill K, et al. Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole. Naunyn Schmiedebergs Arch Pharmacol. 2004 Oct;370 (4) :227-37. |[4]Heel RC, et al. Econazole: a review of its antifungal activity and therapeutic efficacy. Drugs. 1978 Sep;16 (3) :177-201.|[5]Liu CF, et al. Antioxidative natural product protect against econazole-induced liver injuries. Toxicology. 2004 Mar 1;196 (1-2) :87-93.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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