Vav Polyclonal Antibody

CAT: 0749-ABP56489-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP56489-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
VAV1 (vav guanine nucleotide exchange factor 1) is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for VAV1.
Description
Rabbit Anti-Vav Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
VAV1; VAV; Proto-oncogene vav
Gene ID
7409
Accession Number
P15498
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human Vav around the non-phosphorylation site of Y174
Clonality
Polyclonal
Tag
Proto-oncogene vav
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
100kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Vav Polyclonal Antibody detects endogenous levels of Vav protein.
Observed Molecular Weight
100
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Other Product Names
VAV1; VAV; Proto-oncogene vav
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P15498
Isotype
Rabbit IgG

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