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Patched Polyclonal Antibody

CAT: 0749-ABP55882-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP55882-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PTCH1 (patched 1) encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of PTCH1 have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
Description
Rabbit Anti-Patched Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
PTCH1; PTCH; Protein patched homolog 1; PTC; PTC1
Gene ID
5727
Accession Number
Q13635
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the N-terminal region of human Patched at AA range: 1-80
Clonality
Polyclonal
Tag
Protein patched homolog 1
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
160kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Patched Polyclonal Antibody detects endogenous levels of Patched protein.
Observed Molecular Weight
160
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
Other Product Names
PTCH1; PTCH; Protein patched homolog 1; PTC; PTC1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q13635
Isotype
Rabbit IgG

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