Patched Polyclonal Antibody

• Background :

  PTCH1 (patched 1) encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of PTCH1 have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

• Description :

  Rabbit Anti-Patched Polyclonal Antibody

• Product Name Alternative :

  PTCH1; PTCH; Protein patched homolog 1; PTC; PTC1

• Gene ID :

  5727

• Accession Number :

  Q13635

• Reactivity :

  Human, Mouse

• Immunogen :

  Synthesized peptide derived from the N-terminal region of human Patched at AA range: 1-80

• Clonality :

  Polyclonal

• Tag :

  Protein patched homolog 1

• Applications :

  WB, IHC, IF, ELISA

• Purification Method :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration :

  1 mg/ml

• Molecular Weight :

  160kD

• Precautions :

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions :

  Gel pack with blue ice.

• Storage Conditions :

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes :

  Patched Polyclonal Antibody detects endogenous levels of Patched protein.

• Observed Molecular Weight :

  160

• Formulation :

  Liquid solution

• Buffer pH :

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applications Notes :

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200

• Other Product Names :

  PTCH1; PTCH; Protein patched homolog 1; PTC; PTC1

• Tested Applications :

  WB, IHC, IF, IP, ELISA

• Host or Source :

  Rabbit

• Accession Number URL :

  http://www.uniprot.org/uniprot/Q13635

• CAS Number :

  9007-83-4

• Isotype :

  Rabbit IgG