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MGluR2 Polyclonal Antibody

CAT: 0749-ABP54675-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP54675-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for GRM2.
Description
Rabbit Anti-mGluR2 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
GRM2; GPRC1B; MGLUR2; Metabotropic glutamate receptor 2; mGluR2
Gene ID
2912
Accession Number
Q14416
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the Internal region of human mGluR2 at AA rangle: 210-290
Clonality
Polyclonal
Tag
Metabotropic glutamate receptor 2
Applications
IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
MGluR2 Polyclonal Antibody detects endogenous levels of mGluR2 protein.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications.
Other Product Names
GRM2; GPRC1B; MGLUR2; Metabotropic glutamate receptor 2; mGluR2
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q14416
Isotype
Rabbit IgG

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