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MGluR1 Polyclonal Antibody

CAT: 0749-ABP54673-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP54673-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GRM1 encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Description
Rabbit Anti-mGluR1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
GRM1; GPRC1A; MGLUR1; Metabotropic glutamate receptor 1; mGluR1
Gene ID
2911
Accession Number
Q13255
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the Internal region of human mGluR1 at AA rangle: 220-300
Clonality
Polyclonal
Tag
Metabotropic glutamate receptor 1
Applications
IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
MGluR1 Polyclonal Antibody detects endogenous levels of mGluR1 protein.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Other Product Names
GRM1; GPRC1A; MGLUR1; Metabotropic glutamate receptor 1; mGluR1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q13255
Isotype
Rabbit IgG

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