Dexras2 Polyclonal Antibody

• Background :

  RASD2 belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The RASD family member 2 functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO) . This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD) . Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients.

• Description :

  Rabbit Anti-Dexras2 Polyclonal Antibody

• Product Name Alternative :

  RASD2; TEM2; GTP-binding protein Rhes; Ras homolog enriched in striatum; Tumor endothelial marker 2

• Gene ID :

  23551

• Accession Number :

  Q96D21

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Synthesized peptide derived from the C-terminal region of human Dexras2 at AA rangle: 190-270

• Clonality :

  Polyclonal

• Tag :

  GTP-binding protein Rhes

• Applications :

  WB, ELISA

• Purification Method :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration :

  1 mg/ml

• Molecular Weight :

  35kD

• Precautions :

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions :

  Gel pack with blue ice.

• Storage Conditions :

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes :

  Dexras2 Polyclonal Antibody detects endogenous levels of Dexras2 protein.

• Observed Molecular Weight :

  35

• Formulation :

  Liquid solution

• Buffer pH :

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applications Notes :

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.

• Other Product Names :

  RASD2; TEM2; GTP-binding protein Rhes; Ras homolog enriched in striatum; Tumor endothelial marker 2

• Tested Applications :

  WB, IHC, IF, IP, ELISA

• Host or Source :

  Rabbit

• Accession Number URL :

  http://www.uniprot.org/uniprot/Q96D21

• CAS Number :

  9007-83-4

• Isotype :

  Rabbit IgG