Dexras2 Rabbit Polyclonal Antibody

• Background :

  This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO) . This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD) . Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016], function:Binds to GTP and possesses intrinsic GTPase activity. May play a role in mediating signal transduction (By similarity) . May be involved in mediating the insulin secretory response to efaroxan., similarity:Belongs to the small GTPase superfamily. RasD family., subunit:Monomer ., tissue specificity:Pancreatic endocrine cells (islets of Langerhans) .

• Product Name Alternative :

  RASD2; TEM2; GTP-binding protein Rhes; Ras homolog enriched in striatum; Tumor endothelial marker 2

• Gene Name :

  RASD2

• Gene ID :

  23551

• Swiss Prot :

  Q96D21

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB, ELISA

• Purification :

  Affinity purification

• Dilution :

  WB 1:500-1:2000, ELISA 1:20000-1:40000

• Form :

  Liquid

• Buffer :

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

• Modification :

  Unmodified

• Molecular Weight :

  35kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype :

  IgG