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Sgo2 Polyclonal Antibody

CAT: 0749-ABP53905-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP53905-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity) . Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.
Description
Rabbit Anti-Sgo2 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
SGOL2; Shugoshin-like 2; Shugoshin-2; Sgo2; Tripin
Gene ID
151246
Accession Number
Q562F6
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the Internal region of human Sgo2 at AA rangle: 650-730
Clonality
Polyclonal
Tag
Shugoshin-like 2
Applications
IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Sgo2 Polyclonal Antibody detects endogenous levels of Sgo2 protein.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
Other Product Names
SGOL2; Shugoshin-like 2; Shugoshin-2; Sgo2; Tripin
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q562F6
Isotype
Rabbit IgG

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