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NCX1 Polyclonal Antibody

CAT: 0749-ABP52834-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP52834-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
In cardiac myocytes, Ca (2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca (2+) concentration during contraction is primarily due to release of Ca (2+) from intracellular stores. However, some Ca (2+) also enters the cell through the sarcolemma (plasma membrane) . During relaxation, Ca (2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca (2+) that entered across the sarcolemma must be extruded from the cell. The Na (+) -Ca (2+) exchanger is the primary mechanism by which the Ca (2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.
Description
Rabbit Anti-NCX1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
SLC8A1; CNC; NCX1; Sodium/calcium exchanger 1; Na (+) /Ca (2+) -exchange protein 1
Gene ID
6546
Accession Number
P32418
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the Internal region of human NCX1 at AA range: 270-350
Clonality
Polyclonal
Tag
Sodium
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
108kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
NCX1 Polyclonal Antibody detects endogenous levels of NCX1 protein.
Observed Molecular Weight
108
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:5000; Not yet tested in other applications.
Other Product Names
SLC8A1; CNC; NCX1; Sodium/calcium exchanger 1; Na (+) /Ca (2+) -exchange protein 1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P32418
Isotype
Rabbit IgG

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