Tyk 2 Polyclonal Antibody

• Background :

  TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. Non-receptor tyrosine-protein kinase TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

• Description :

  Rabbit Anti-Tyk 2 Polyclonal Antibody

• Product Name Alternative :

  TYK2; Non-receptor tyrosine-protein kinase TYK2

• Gene ID :

  7297

• Accession Number :

  P29597

• Reactivity :

  Human, Mouse, Monkey

• Immunogen :

  Synthesized peptide derived from human Tyk 2 around the non-phosphorylation site of Y1054

• Clonality :

  Polyclonal

• Tag :

  Non-receptor tyrosine-protein kinase TYK2

• Applications :

  WB, IHC, IF, ELISA

• Purification Method :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration :

  1 mg/ml

• Molecular Weight :

  134kD

• Precautions :

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions :

  Gel pack with blue ice.

• Storage Conditions :

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes :

  Tyk 2 Polyclonal Antibody detects endogenous levels of Tyk 2 protein.

• Observed Molecular Weight :

  134

• Formulation :

  Liquid solution

• Buffer pH :

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applications Notes :

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications.

• Other Product Names :

  TYK2; Non-receptor tyrosine-protein kinase TYK2

• Tested Applications :

  WB, IHC, IF, IP, ELISA

• Host or Source :

  Rabbit

• Accession Number URL :

  http://www.uniprot.org/uniprot/P29597

• CAS Number :

  9007-83-4

• Isotype :

  Rabbit IgG