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Tyk 2 Polyclonal Antibody

CAT: 0749-ABP52659-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP52659-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. Non-receptor tyrosine-protein kinase TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Description
Rabbit Anti-Tyk 2 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
TYK2; Non-receptor tyrosine-protein kinase TYK2
Gene ID
7297
Accession Number
P29597
Reactivity
Human, Mouse, Monkey
Immunogen
Synthesized peptide derived from human Tyk 2 around the non-phosphorylation site of Y1054
Clonality
Polyclonal
Tag
Non-receptor tyrosine-protein kinase TYK2
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
134kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Tyk 2 Polyclonal Antibody detects endogenous levels of Tyk 2 protein.
Observed Molecular Weight
134
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications.
Other Product Names
TYK2; Non-receptor tyrosine-protein kinase TYK2
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P29597
Isotype
Rabbit IgG

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