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APLP-2 Polyclonal Antibody

CAT: 0749-ABP50680-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP50680-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
APLP2 encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Description
Rabbit Anti-APLP-2 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
APLP2; APPL2; Amyloid-like protein 2; APLP-2; APPH; Amyloid protein homolog; CDEI box-binding protein; CDEBP
Gene ID
334
Accession Number
Q06481
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the Internal region of human APLP-2 at AA range: 210-290
Clonality
Polyclonal
Tag
Amyloid-like protein 2
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
90-120kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
APLP-2 Polyclonal Antibody detects endogenous levels of APLP-2 protein.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
Other Product Names
APLP2; APPL2; Amyloid-like protein 2; APLP-2; APPH; Amyloid protein homolog; CDEI box-binding protein; CDEBP
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q06481
Isotype
Rabbit IgG

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