SR-1F Polyclonal Antibody

• Background:

  HTR1F (5-Hydroxytryptamine Receptor 1F) is a Protein Coding gene. Diseases associated with HTR1F include migraine with or without aura 1. Among its related pathways are Signaling by GPCR and cAMP signaling pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and serotonin binding. An important paralog of this gene is DRD4. G-protein coupled receptor for 5-hydroxytryptamine (serotonin) . Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Serotonin 5-HT1F receptors, previously known as 5-HT1Ebeta receptors, are located primarily in the hippocampus, cortex and dorsal raphe nucleus. The human 5-HT1F receptor is closely related to the 5-ht1E receptor and its gene has been localized to chromosome 3 (3q11) .

• Description:

  Rabbit Anti-SR-1F Polyclonal Antibody

• Product Name Alternative:

  HTR1F; HTR1EL; 5-hydroxytryptamine receptor 1F; 5-HT-1F; 5-HT1F; Serotonin receptor 1F

• Gene ID:

  3355

• Accession Number:

  P30939

• Reactivity:

  Human, Mouse, Rat, Monkey

• Immunogen:

  Synthesized peptide derived from the Internal region of human SR-1F at AA range: 70-150

• Clonality:

  Polyclonal

• Tag:

  5-hydroxytryptamine receptor 1F

• Applications:

  WB, ELISA, IHC

• Purification Method:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Molecular Weight:

  38kD

• Precautions:

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions:

  Gel pack with blue ice.

• Storage Conditions:

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes:

  SR-1F Polyclonal Antibody detects endogenous levels of SR-1F protein.

• Observed Molecular Weight:

  38

• Formulation:

  Liquid solution

• Buffer pH:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applications Notes:

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000

• Other Product Names:

  HTR1F; HTR1EL; 5-hydroxytryptamine receptor 1F; 5-HT-1F; 5-HT1F; Serotonin receptor 1F

• Tested Applications:

  WB, IHC, IF, IP, ELISA

• Host or Source:

  Rabbit

• Accession Number URL:

  http://www.uniprot.org/uniprot/P30939

• CAS Number:

  9007-83-4

• Isotype:

  Rabbit IgG