HDAC8 Polyclonal Antibody

• Background:

  Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase 8 encoded by HDAC8 belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for HDAC8.

• Description:

  Rabbit Anti-HDAC8 Polyclonal Antibody

• Product Name Alternative:

  HDAC8; HDACL1; CDA07; Histone deacetylase 8; HD8

• Gene ID:

  55869

• Accession Number:

  Q9BY41

• Reactivity:

  Human, Mouse, Rat, Monkey

• Immunogen:

  Synthesized peptide derived from human HDAC8 around the non-phosphorylation site of S39

• Clonality:

  Polyclonal

• Tag:

  Histone deacetylase 8

• Applications:

  WB, IHC, IF, ELISA

• Purification Method:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Molecular Weight:

  42kD

• Precautions:

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions:

  Gel pack with blue ice.

• Storage Conditions:

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes:

  HDAC8 Polyclonal Antibody detects endogenous levels of HDAC8 protein.

• Observed Molecular Weight:

  42

• Formulation:

  Liquid solution

• Buffer pH:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applications Notes:

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200

• Other Product Names:

  HDAC8; HDACL1; CDA07; Histone deacetylase 8; HD8

• Tested Applications:

  WB, IHC, IF, IP, ELISA

• Host or Source:

  Rabbit

• Accession Number URL:

  http://www.uniprot.org/uniprot/Q9BY41

• CAS Number:

  9007-83-4

• Isotype:

  Rabbit IgG