E2F-4/5 Polyclonal Antibody

CAT: 0749-ABP51214-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP51214-01Size:30 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
E2F transcription factor 4 encoded by E2F4 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.
Description
Rabbit Anti-E2F-4/5 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
E2F4; Transcription factor E2F4; E2F-4; E2F5; Transcription factor E2F5; E2F-5
Gene ID
1874/1875
Accession Number
Q16254/Q15329
Reactivity
Human, Mouse, Rat, Monkey
Immunogen
Synthesized peptide derived from the Internal region of human E2F-4/5 at AA range: 30-110
Clonality
Polyclonal
Tag
Transcription factor E2F4
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
44kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
E2F-4/5 Polyclonal Antibody detects endogenous levels of E2F-4/5 protein.
Observed Molecular Weight
44
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
Other Product Names
E2F4; Transcription factor E2F4; E2F-4; E2F5; Transcription factor E2F5; E2F-5
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q16254
Isotype
Rabbit IgG

Related Products

CatalogName
ABP54039-01E2F-5 Polyclonal Antibody
ABP53053-01E2F-4 Polyclonal Antibody
ABP50101-01E2F-4 (Acetyl Lys96) Polyclonal Antibody
ABP0184E2F-1 Polyclonal Antibody
ABP51215-01E2F-6 Polyclonal Antibody
ABP51212-01E2F-1 Polyclonal Antibody
ABP57536-01E2F-1 Polyclonal Antibody
ABP51213-01E2F-2 Polyclonal Antibody
ABP58445-01E2F-1 Polyclonal Antibody
ABP58443-01E2F-1 (Acetyl-K117) Polyclonal Antibody

Alternative Products

CatalogName
MBS9243465-01E2F-4/5 Polyclonal Antibody
E28PT1444E2F-4/5 Rabbit Polyclonal Antibody
RA24394-01E2F-5 Polyclonal Antibody
UB-GEN-2194E2F-4 Polyclonal Antibody
C0178-01E2F-4/5 Antibody

Popular Products