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DRAK2 Polyclonal Antibody

CAT: 0749-ABP51200-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP51200-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DAP (death associated protein) kinase and ZIP kinase are members of a novel protein kinase family, the members of which have the capacity to mediate apoptosis through their catalytic activities. DAP kinase contains a "death domain" and has been shown to mediate gamma interferon-induced apoptosis. The introduction of DAP kinase into highly metastatic carcinoma clones lacking DAP kinase expression was shown to result in the suppression of metastasis, thus linking suppression of apoptosis to metastasis. ZIP kinase contains a leucine zipper domain, which is necessary for homodimerization and for interaction with other leucine zipper proteins. ZIP kinase dimerizes with ATF-4, an ATF/CREB transcription factor family member that contains a leucine zipper. DRAK1 (DAP kinase-related apoptosis-inducing protein kinase 1) and DRAK2 are DAP kinase related proteins. DRAK1 and DRAK2 are localized to the nucleus, and overexpression of both DRAK proteins in NIH/3T3 cells induces morphological changes associated with apoptosis.
Description
Rabbit Anti-DRAK2 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
STK17B; DRAK2; Serine/threonine-protein kinase 17B; DAP kinase-related apoptosis-inducing protein kinase 2
Gene ID
9262
Accession Number
O94768
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the Internal region of human DRAK2 at AA range: 220-300
Clonality
Polyclonal
Tag
Serine threonine-protein kinase 17B
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
45kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
DRAK2 Polyclonal Antibody detects endogenous levels of DRAK2 protein.
Observed Molecular Weight
45
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
Other Product Names
STK17B; DRAK2; Serine/threonine-protein kinase 17B; DAP kinase-related apoptosis-inducing protein kinase 2
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/O94768
Isotype
Rabbit IgG

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