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DHRS2 Polyclonal Antibody

CAT: 0749-ABP51170-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP51170-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DHRS2 (dehydrogenase/reductase (SDR family) member 2), also known as SDR25C1 or HEP27, is a 258 amino acid protein that localizes to the nucleus and belongs to the short-chain dehydrogenase/reductase (SDR) family. Functioning as an NADPH-dependent dicarbonyl reductase, DHRS2 is thought to inhibit cell replication by either converting cortisone in cortisol, or by catalyzing the oxidation of androgen and estrogen. The gene encoding DHRS2 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD) . The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder α1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.
Description
Rabbit Anti-DHRS2 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
DHRS2; Dehydrogenase/reductase SDR family member 2; Dicarbonyl reductase HEP27; Protein D
Gene ID
10202
Accession Number
Q13268
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the Internal region of human DHRS2 at AA range: 80-160
Clonality
Polyclonal
Tag
Dehydrogenase
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
27kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
DHRS2 Polyclonal Antibody detects endogenous levels of DHRS2 protein.
Observed Molecular Weight
27
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Other Product Names
DHRS2; Dehydrogenase/reductase SDR family member 2; Dicarbonyl reductase HEP27; Protein D
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q13268
Isotype
Rabbit IgG

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